Infrequent cause of dyspnea and desaturation unresponsive to oxygen therapy




Santiago Campbell-Silva, Servicio de Medicina Interna, Clínica Mediláser, Florencia, Colombia
Sandra Alarcón-Calderón, Servicio de Medicina Interna, Clínica Mediláser, Florencia, Colombia
Santiago Campbell-Quintero, Departamento de Medicina Interna, Hospital Hermanos Ameijeiras, Habana, Cuba
Sebastián Campbell-Quintero, Servicio de Cardiología, Clínica Mediláser, Hospital María Inmaculada, Florencia, Colombia


Platypnea-orthodeoxia syndrome is a rare and underdiagnosed condition. It is characterized by dyspnea and hypoxemia in the standing position with improvement in the dorsal decubitus position. Diagnosing is a challenge, and its ignorance can lead to unnecessary studies. Generally, it is due to anatomical and functional defects that generate a right-left shunt. We present the case of a patient with atrial septal defect, atrial septal aneurysm and aortic dilatation, an unusual combination. This is the first reported case in Colombia.



Keywords: Platypnea-orthodeoxia syndrome. Refractory hypoxemia. Unexplained dyspnea. Unexplained desaturation. Prone position.