Caridad Chao-Pereira, Departamento de Medicina Interna, Protocolo de Insuficiencia Cardíaca, Hospital Clínico Quirúrgico Docente Hermanos Ameijeiras, La Habana, Cuba
Julián Treviño-González, Departamento de Medicina Interna, Protocolo de Insuficiencia Cardíaca, Hospital Clínico Quirúrgico Docente Hermanos Ameijeiras, La Habana, Cuba
Dorian Castellanos-Almaguer, Departamento de Medicina Interna, Protocolo de Insuficiencia Cardíaca, Hospital Clínico Quirúrgico Docente Hermanos Ameijeiras, La Habana, Cuba
Ángela R. Gutiérrez, Departamento de Medicina Interna, Protocolo de Insuficiencia Cardíaca, Hospital Clínico Quirúrgico Docente Hermanos Ameijeiras, La Habana, Cuba
Eloisa Casas-Morell, Departamento de Medicina Interna, Protocolo de Insuficiencia Cardíaca, Hospital Clínico Quirúrgico Docente Hermanos Ameijeiras, La Habana, Cuba
Snayder J. Pérez-Goelkel, Departamento de Medicina Interna, Protocolo de Insuficiencia Cardíaca, Hospital Clínico Quirúrgico Docente Hermanos Ameijeiras, La Habana, Cuba
Introduction: Heart failure (HF) is a global health problem. As life expectancy increases, so does HF’s prevalence, disability, and mortality, imposing high costs on the economy. Currently, it is considered a chronic inflammatory disease. Objective: To evaluate the relationship between body mass index, high-sensitivity C-reactive protein (hsCRP) blood levels, and mortality in patients with chronic HF. Methods: An observational, analytical, prospective cohort study was carried out in 110 patients who attended the protocolized HF clinic at Hospital Clínico Quirúrgico Hermanos Ameijeiras. The probability of being free of death (survival) was evaluated using the Kaplan-Meier method. The Cox regression model was used to estimate the prognostic value of hsCRP for mortality, according to body mass index categories. Results: A significant relationship (p = 0.006) was found for mortality in overweight patients with a high hsCRP. In the logistic regression model, the variable associated with mortality was hsCRP, which showed significant values (p = 0.004) with confidence intervals that excluded the unit (95% CI: 1.871-25.785). Conclusions: In the presence of optimal treatment, being overweight and obese did not increase mortality. Overweight patients’ better prognosis was related to lower blood concentrations of hsCRP.
Keywords: Heart failure. C-reactive protein. Mortality. Overweight. Obesity. Body mass index.
